To establish a gas chromatography-mass spectrometry method to determine the migration of lubricants from food contact materials.MethodsFood-simulating solvents of water, 10% ethanol, 3% acetic acid were used for soaking food contact materials. After purification, enrichment, and trifluoroacetic acid anhydride derivatization, 4 lubracant migrants were determined by gas chromatography-mass spectrometry (GC-MS).ResultsThe linearity range for oleic acid amide and stearic amide was 0.2-10 mg/L, and it was 1.0-20 mg/L for erucic acid amide and mountain do amide. The limit of quantification was 0.028-0.17 mg/L, and the recoveries were 89.2%-97.6%, with relative standard deviation(RSD) of 1.1%-5.4%.ConclusionThe method was simple, rapid, accurate, and suitable for the detection of lubricant migration in food contact materials.