Di-(2-ethylhexyl)-phthalate (DEHP) is a widely used phthalic acid esters plasticizer, which might migrate to environment through plastic products or directly migrate from packaging materials to food, polluting the air, water, soil and food. DEHP can induce reproductive and developmental toxicity, immunotoxicity, embryotoxicity, hepatotoxicity, neurotoxicity and carcinogenicity. At the same time, it can also impose a certain influence on the endocrine system. The endocrine-disrupting property and neurotoxicity of DEHP and the interaction between them was reviewed in this paper.