To establish a method for determining 14 organophosphorus pesticides(OPs) and 7 pyrethroids pesticides (PPs) in 5 kinds of food by GPC and GC-MS/MS, and find the advantages of GPC and GC-MS/MS in analyzing pesticide residues in food.MethodsFive kinds of food including leeks, Chinese cabbage, pepper, pork and fish were pretreated with GPC, and the samples were analyzed qualitatively and quantitatively by GC-MS/MS. ResultsThe linear correlation coefficients of 14 OPs and 7 PPs were above 0.995. The limit of quantification was in the range of 0.002-0.034 mg/kg. The relative standard deviation (RSD) was 2.9-10.2%, and the rates of recovery were 78.6-108.3% for leek and pork samples spiked with 0.05,0.10 and 0.20 mg/kg of 14 OPs and 7 PPs. ConclusionThe method was widely used, highly sensitive, reliable, accurate, and suitable for analysis of pesticide residues in many kinds of food.