To establish the rapid and accurate determination method of Al、Cr、Mn、Fe、Ni、Cu、Zn、As、Se、Cd、Sb、Pb 12 metals in soy sauce by ICP-MS.MethodsCombined with the high salinity properties of soy sauce, an accurate determination method was established through means of sample matrix dilution、the appropriate isotope、the He collision cell pattern and internal calibration. ResultsThe linear range of 12 metals was 0.2 μg/L-1.0 mg/L, r>0.999,MDL was 0.001-0.003 mg/L, RSD < 10%, recovery rate was 80%-110%. ConclusionThe ICP-MS method was less interference、accurate、convenient and rapid for determination of metals in soy sauce and other high salt food.