To study the current status of serotype and drug resistance in Vibrio parahaemolyticus in food poisoning, diarrhea patients and the environment in Haizhu district of Guangzhou.Methods17strains from food poisoning, 27 strains from sporadic diarrhea patients and 17 strains from the environment were identified with biochemical and serotyping tests. Antibiotic resistance test of the isolates was further performed. ResultsSeventeen strains from food poisoning could be divided into 6 serotypes, and the prevalent serotype was O3∶K6 (12/17,0.6%).Twenty-seven trains from diarrhea patients could be divided into 10 serotypes, and the prevalent serotype was O3∶K6 (17/27,3.0%). Seventeen strains from the environment could be divided into 11 serotypes, but the serotypes were scattered. In addition, there were three dual-resistantstrains, and one triple-resistantstrain in those 61 strains.ConclusionThe strains were on different levels of antibiotic resistance, and the prevalent serotype was O3∶K6 in Haizhu district of Guangzhou.