To investigate the influence of trace element strontium on the content of rats' serum ALT, AST, BUN, Cr, LDH, HDL, triglycerides and total cholesterol.MethodsWistar rats weighing 150-170g, half male and half female, were randomly divided into group A, B, C, D (mineral water with Sr 2,4, 6,8mg/L) and group E (tap water). Each group had 42rats(n=42). 6rats in each group were randomly sacrificed at 0,1, 2,3, 4,5and 6th month, and blood samples were collected. Serum ALT, AST, BUN, Cr, LDH, HDL, triglycerides and total cholesterol were tested. Hearts, livers and kidneys were stained by HE for morphology analysis. ResultsThere was no significant difference in the content of serum ALT, AST, Cr, LDH, HDL, triglycerides and total cholesterol between group A, B, C, D and E at each time point.(P>0.05). The contents of BUN in group A was significantly lower than that in group E (P<0.05). There was no significant difference in the morphology of kidney, heart and liver between group A, B, C, D and E. ConclusionTrace element strontium had no significant effect on the content of serum ALT, AST, LDH, BUN, Cr, HDL, triglycerides, total cholesterol, and the morphology of kidney, heart and liver in rats.