To observe the intervention effect of GTF functional milk on IGT mice and provides the basis for develop milk to intervent IGT effectively.MethodsExcept for normal control group, IGT mice of model control group, metformin group, chromium-rich yeast group, ordinary milk group, low, medium and high dose of GTF functional milk group were adopted D-galactose by intraperitoneal injection. After 14days, at the same time the mice were adopted by intragastric administration to observe the fasting blood sugar, 2-hour blood glucose, triglyceride, total cholesterol, high-density lipoprotein cholesterol, low density lipoprotein cholesterol, fasting insulin, insulin resistance index 42days later. Results2-Hour blood glucose, fasting insulin, insulin resistance index of low, medium and high dose of GTF functional milk groups compared with the model control group, the difference was statistically significant (P＜0.01, P＜0.05). Triglyceride, total cholesterol, high-density lipoprotein cholesterol of medium and high dose of GTF functional milk groups compared with the model control group, the difference was statistically significant (P＜0.01, P＜0.05). 2-Hour blood glucose, triglyceride, total cholesterol, insulin resistance index of medium and high dose of GTF functional milk groups compared with the chromium-rich yeast group, the difference was statistically significant (P＜0.05). Fasting insulin, insulin resistance index of high dose of GTF functional milk group compared with the chromium-rich yeast group, the difference was statistically significant (P＜0.05).ConclusionThe GTF functional milk could reduce the levels of blood glucose and blood lipid and improve insulin resistance on IGT mice. After cow''s biotransformation, its biological activity could be further improved.