To evaluate the influence of sFat-1transgenic pork on the blood routine and biochemical and immune indicators of mice.Methods Granular compound feed with low and high dosage of sFat-1transgenic pork or pork control and basal feed control were administered orally to five groups of mice respectively for 30days. Blood routine and biochemical indicators, immunoglobulin and the percentage of lymphocytes in peripheral blood were observed.Results There was no significant difference between the five groups on blood routine and immunoglobulin; the serum BUN concentration was significantly higher in high-dosage sFat-1transgenic pork group than control group in both male and female (P＜0.05); the percentage of lymphocytes (CD3⁺CD4⁺) in peripheral blood of female was significantly higher in low-dosage sFat-1transgenic pork group than low-dosage pork control group (P＜0.05), while the percentage of lymphocytes (CD3⁺CD8⁺) of female mice was significantly higher in high-dosage sFat-1transgenic pork group than low-dosage pork control group(P＜0.05).Conclusion There was no influence of sFat-1transgenic pork on blood routine and biochenicnt and immune indicators of mice at the given dosage in the study.