To investigate the effect of transgenic Bt rice (TT51) exposure on reproductive system development of male filial generation of Wistar rats. MethodsMarket rice, TT51and its parent were continuously administered to the female and male rats of parental generation for 70days, and then produced the filial generation. The female parents were continued to feed with test samples during gestation and lactation. Filial generation male rats were administered with ordinary feed for 70days after weaned, and body weight, food consumption and growth status were recorded every week. The young male rats were sacrificed on the 70th day for blood routine, blood biochemistry, serumal hormone level, reproductive organ weight , sperm parameter and other target examinations. [WT5"HZ]Results No significant defference was observed between the TT51rice , market rice and its parent rice rice groups on body weight, food consumption, blood routine, blood biochemistry, serumal hormone level, sperm parameter. ConclusionTT51rice exposure had no observed adverse effect on the reproductive system development of male filial generation.