Objective To monitor and analyze the contamination of Salmonella during the process of pig cultivation and slaughting in Kaifeng. Methods A total of 187samples of pig feces, anal swab, carcass smear and mesenteric lymph node were randomly collected from different sources. Samples were isolated and identified according to GB 4789.4—2010to monitor the contamination of Salmonella. Results Salmonella was detected in 4.5% of the pig feces, 16.4% of the anal swab, 34.5% of the carcass smear and 27.3% of the mesenteric lymph node. The detection rate was significantly different in different seasons (P<0.05). The positive isolates were distributed in 5groups, containing 14serotypes, mainly S.agona and S.derby. Conclusion Slaughter process is the critical point of pork Salmonella cross-contamination. Comprehensive measures should be taken in order to effectively control the Salmonella contamination in pork product. \=