Objective To verify the suspected cluster cases detected by active surveillance system of Salmonella molecular subtyping via pulsed field gel electrophoresis through epidemiological investigation and to propose preventive and control measures. Methods We analyzed the distributions of time, location and demographic characteristics by descriptive epidemiology, and investigated the food exposure histories. Then we collected food samples and Emu'' analswabs for Salmonella isolation. ResultsA foodborne disease outbreak of 5cases induced by Salmonella enterica Serovars Weltevreden was detected by the active surveillance system in Haizhu district, Guangzhou city, and the undercooked Emu''s meat product were the suspected food. Conclusion This is the first foodborne disease outbreak detected by active surveillance system via pulsed field gel electrophoresis in Guangdong Province, and the government should pay more attention to the application of the new technology and its consequent challenge on the outbreak response coordination mechanism.\=