A new analytical method was developed to simultaneously determine fluoride ion, chloride ion, sulfate and nitrate in calcium phosphate. MethodThe chromatography conditions were optimized, and the anions of calcium phosphate were determined by ion chromatography with elution of sodium carbonate and sodium hydroxide. The pesticides were identified by retention time and quantified by external standards. ResultsThe results showed that the four ions were separated with high sensitivity in the optimized experiment conditions. Concentration of each ion was linear with its peak area, and the correlation coefficient was above 0.999. The RSD of the detection results was less than 3% (n=9), and the recoveries were 80%-105%. Conclusion This method is simple, sensitive and rapid for the simultaneous determination of four kinds of anions content in calcium phosphate.