To investigate antibiotic resistance of Salmonella in Nantong and characterization of related molecule mechanism of integron mediated resistance transmit. Methods 67Salmonella strains were isolated in Nantong area during 2008to 2011. The susceptibility to antibiotics was tested by the disk diffusion assay. Conjugational transfer test was carried out using donor (Salmonella) and receiver (Escherichia coli.). The different integron genes carried by donor and receiver were detected by PCR. Results74.6%(50/67) strains was antibiotic resistant, 31.3%(21/67) were multidrug resistant. ClassⅠ integrons were identified in 20.9%(14/67) strains of Salmonella. The antibiotic resistant genes can transmit from Salmonella to Escherichia coli. meditated by classⅠ. Conclusion Multidrug resistance was frequently identified in Salmonella in Nantong area. ClassⅠintegron was an important factor of antibiotic resistance transmit in Salmonella and other bacillus.