Objective To establish a method based on solid-phase extraction and gas chromatography-mass spectrometry(GC/MS) for the determination of 3-chloro-1,2-propanediol(3-MCPD),1,3-dichloro-2-propanol(1,3-DCP) and 2,3-dichloro-1-propanol(2,3-DCP) in soy sauce.Methods Soy sauce samples were spiked with deuterium-labeled isotope internal standards and loaded on market-available SPE cartridges,then the analytes were extracted with ethyl acetate and derivatized with N-heptafluorobutyrylimidazole(HFBI).The ...