In order to promote management of lab instruments and improve management regulation of pubic health laboratories by which laboratory instruments can be used with high efficiency to provide fair and exact data, some issues on how to manage public health instruments are discussed. These issues include integrated program files, practice guideline and record files. Adjustment of some instruments, maintenance of small instruments, safety use of instruments and allocation of personnel were also discussed. Some advices which may help improve management level of laboratory and competitive power with international laboratories are put forward.