To investigate antibiotic resistance of Cronobacter sakazakii isolated from imported dairy products. Methods100strains of Cronobacter sakazakii were tested for antibiotic susceptibility by disk diffusion recommended by the National Committee of Clinical laboratory Standard. Results All strains were sensitive to Mezlocillin, Imipenem, Meropenem, Gentamicin, Amikacin, Kanamycin, Tobramycin, Chloramphenicol, Cefepime, Cefoperazone, Cefotaxime Sodium, Ceftazidime, Pentahydrate, Ciprofloxacin and Norfloxacin, while resistant to Proctaphlin Sodium. The ratio of resistant strains to Ampicillin, Cefalotin, Cefazolin Sodium, Sodium and Tetracycline was 65%, 17%, 3% and 2%, respectively. The ratio of intermediate resistant strains to Ampicillin, Cefazolin Sodium, Cefalotin Sodium, Ceftriaxone Sodium, Tetracycline was 25%, 23%, 6%, 2% and 1% respectively. 13strains were multiresistant to 3kinds of antibiotics and 4strain was multiresistant. ConclusionCronobacter sakazakii strains isolated from imported dairy products were susceptible to most of the tested antibiotics, but resistance were increasing. In this study, All drug resistant strains to oxacillin. Hereby, the issue of Cronobacter sakazakii multiresistance should arouse abroad attention worldwide.