Objective Developed a method based on solid phase extraction(SPE) combined with gas chromatography-mass spectrometry (GC-MS) to determine 1,2-propanediol in milk. Methods The precipitation technology of protein and solid phase extraction，Pretreatment technology in milk testing，were carefully investigated. Protein of sample milk was precipitated by potassium ferrocyanide and zinc acetate, then cleaned-up by silicious earth solid phase extraction (SPE). Results In the range of 0.1 ~ 50 μg/mL，1,2-propanediol had good linear with R2 0.9994 under the selected conditions. The recovery and relative standard deviation(RSD) were 81.8～86.5 % and 3.1～5.8 % at 0.33、0.5 and 2.0 mg/kg spiked. And the minimum detection concentration of the method was 0.1 mg/kg. Conclusion The developed method has proved convenient, environmental- friendly, accurate and sensitive.