Objective To understand the pollution levels of elements and pesticide residues of ganoderma lucidum in Jilin Province, and the cumulative exposure health risk of introducing PPb，Cd, As, Hg 4 kinds of hazardous elements and pesticide residues when consuming ganoderma lucidum. Methods 48 samples of ganoderma lucidum planted in Jilin Province were collected, and the contents of 37 elements and 57 pesticide residues were tested in accordance with the national food safety standard method. The exposure level of major Pb，Cd, As, Hg and pesticide residues was calculated by deterministic point assessment method and the cumulative exposure level of hazard index (HI) and relative efficacy factor (RPF). Results Pb，Cd, As, Hg were widely detected in Jilin Province, with the detection rate between 95.8% and 100%, while the excess rates of Pb and Hg were 2.08% and 4.17%, respectively. The average daily exposure level of the four elements was between 0.0002 and 0.0011 μ g / kg BW. The exposure level of the high consumption population was between 0.0003 and 0.0034 μ g / kg BW. For the cumulative exposure of Pb, Cd, As, Hg, the HI value of the average consumption level was 0.200% and the HI value of the high consumption population was 0.628%. The detection rate of the 5 pyrethroid pesticides was between 4.17 and 16.7%, the acute exposure level was between 4.64×10-5-5.65×10-4mg/kg BW，the acute cumulative exposure level was 1.25×10-3mg/kg BW. The exposure limit (margin of exposure, MOE) value of pyrethroid pesticides was 8800. Conclusion Based on HI method and RPF method, the exposure assessment of hazardous elements and pyrethroid pesticide residues in the consumer population of ganoderma lucidum in Jilin Province was evaluated. The risk of chronic cumulative exposure of elements and the risk of acute cumulative exposure of pyrethrin pesticide residues were at acceptable levels.