超重肥胖儿童非酒精性脂肪肝与内脏脂肪指数的相关性研究
作者:
作者单位:

1.鹤壁市市场监管综合行政执法支队,河南 鹤壁 458030;2.鹤壁市疾病预防控制中心, 河南 鹤壁 458030;3.鹤壁市人民医院营养科,河南 鹤壁 458030

作者简介:

周新峰 男 副主任医师 研究方向为营养与食品卫生 E-mail:zhouxinfenghb@163.com

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中图分类号:

R155

基金项目:


Correlation analysis between nonalcoholic fatty liver disease and visceral adiposity index of overweight and obese children
Author:
Affiliation:

1.Hebi City Market Supervision Comprehensive Administrative Law Enforcement Detachment, He’nan Hebi 458030, China;2.Hebi Center for Disease Control and Prevention, He’nan Hebi 458030, China;3.Department of Nutrition, Hebi People’s Hospital, He’nan Hebi 458030, China

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    摘要:

    目的 对鹤壁市超重肥胖儿童非酒精性脂肪肝(NAFLD)与内脏脂肪指数(VAI)情况及相关性进行分析,以期为早期预防肥胖超重儿童发生NAFLD提供理论参考。方法 择2020年5月至2021年5月于鹤壁市疾病预防控制中心体检的1013例一年级儿童,筛选出肥胖超重儿童243例,依据其NAFLD患病情况分为非NAFLD组和NAFLD组,对比两组患儿基础临床资料、VAI、血脂相关指标及胰岛素抵抗指数(HOMD-IR),以二元Logistic回归分析单因素显著差异的因子与NAFLD间的相关性。结果 本研究从243例肥胖超重儿童中筛查出46例NAFLD患儿,占比18.93%。NAFLD组患儿女童数、VAI、腰围、BMI、HOMA-IR及TG均显著高于非NAFLD组,男童数、HDL-C显著低于非NAFLD组(P<0.05)。两组TC、年龄及LDL-C无显著差异(P>0.05)。Spearman秩相关分析知,肥胖超重儿童HDL-C与NAFLD间呈显著负相关(P<0.01),TG(P<0.01)、HOMA-IR(P<0.01)和VAI(P<0.05)与NAFLD间呈显著正相关。排除混杂因素后经二元Logistic回归分析可知,肥胖超重儿童性别、VAI及HOMA-IR均与NAFLD有密切关系,其中,男童、VAI、HOMA-IR水平上升均可使患儿患NAFLD概率显著增加(P<0.05)。结论 鹤壁市超重肥胖儿童发生NAFLD与其VAI水平密切正相关,VAI上升可使其患NAFLD风险显著提升,临床可依据其VAI进行该病的预防与干预。

    Abstract:

    Objective To provide a theoretical reference for early prevention of nonalcoholic fatty liver disease (NAFLD) in obese and overweight children, the situation and correlation of NAFLD and visceral adiposity index (VAI) of overweight and obese children in Hebi city were analyzed.Methods A total of 243 obese and overweight children were screened from 1013 first-grade children who accepted physical examination at Center for Disease Control and Prevention in Hebi City from May 2020 to May 2021. They were divided into non-NAFLD group and NAFLD group. The basic clinical data, VAI, related blood lipid indexes, and insulin resistance index (HOMD-IR) between the two groups were compared. The correlation between single factors with significant differences and NAFLD were analyzed by binary logistic regression.Results Forty-six children with NAFLD were screened from 243 obese and overweight children, accounting for 18.93%. The number of girls, VAI, waist circumference, BMI, HOMA-IR and TG in the NAFLD group were higher than the non-NAFLD group significantly (P<0.05). The number of boys and HDL-C in the NAFLD group were lower than the non-NAFLD group significantly (P<0.05). There was no significant difference in TC, age and LDL-C between the two groups (P>0.05). Spearman rank correlation analysis showed that there was a significant negative correlation between HDL-C and NAFLD in obese and overweight children (P<0.05). TG, HOMA-IR and VAI were significantly positive correlated with NAFLD (P<0.05). After excluding the confounding factors, binary logistic regression analysis showed that gender, VAI and HOMA-IR in obese and overweight children were significantly related to NAFLD. Among them, larger numbers of boys and increased levels of VAI and HOMA-IR could increase the probability of NAFLD significantly (P<0.05).Conclusion The occurrence of NAFLD in overweight and obese children in Hebi city is closely and positively related to VAI level. Higher VAI level can significantly increase the risk of NAFLD. Clinical prevention and intervention could be conducted according to their VAI level.

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周新峰,刘国清,白建红.超重肥胖儿童非酒精性脂肪肝与内脏脂肪指数的相关性研究[J].中国食品卫生杂志,2023,35(2):254-258.

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  • 收稿日期:2021-10-07
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  • 在线发布日期: 2023-04-18
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