Objective To analyze the incidence and epidemiological characteristics of Vibrio parahaemolyticus infection in Liaoning Province, and to provide scientific basis for prevention and control measures. To analyze the incidence and epidemiological characteristics of Vibrio parahaemolyticus infection in Liaoning Province, and to provide basis for the scientific formulation of prevention and control measures. Methods The case information of Vibrio parahaemolyticus infection in Liaoning from 2014 to 2019 was collected, and the stool samples of patients were collected for detection. SPSS 17.0 software was used for statistical analysis. The Mantel-Haenszel was used to calculate the OR and 95%CI of different sex, age, occupation and regions. The case information of Vibrio parahaemolyticus infection in Liaoning from 2014 to 2019 was collected, and the stool samples of patients were collected for Vibrio parahaemolyticus detection. SPSS 17.0 software was used for statistical analysis.The Mantel-Haenszel was used to calculate the OR and 95%CI of Vibrio parahaemolyticus test for deferent patients of the sex, age, occupation, and regions.Results Detection rate of Vibrio parahaemolyticus was 4.37% from 2014 to 2019 in Liaoning Province. There were significant differences in the patients of Vibrio parahaemolyticus among different regions (5.59% and 2.86%, χ²= 87.627, P<0.01), age (χ²=122.612, P<0.01) and occupations (χ² =139.107, P<0.01). 376 cases were between 25 and 44 years old with the proportion of 43.37% (376/867). There were obvious seasonal characteristics, and the peak time of detection rate was in summer. Main exposed food were aquatic animals and their products (52.14%, 390/748), meat and their products (12.97%, 97/748). There were significant differences in the patients of Vibrio parahaemolyticus among different regions (5.59% and 2.86%, χ²=87.627, P<0.01), age (χ²=122.61, P<0.01) and occupations (χ²=139.107, P<0.01). 376 case of patients were between 25 and 44 years old, with the proportion of 43.37% (376/867).There were obvious seasonal characteristics, and the peak time of detection rate was in summer. Main exposed food were aquatic animals and their products (52.14%, 390/748)and aquatic animals and their products(12.97%, 97/748). Conclusion Vibrio parahaemolyticus is one of the important pathogens of foodborne diseases in Liaoning Province. Vibrio parahaemolyticus is one of the important pathogens of foodborne diseases in Liaoning Province.