杨世锋,孙超,王玉佩,陈玉红,张倩婧,张红.线粒体移植在治疗线粒体缺陷疾病中的研究进展[J].生物化学与生物物理进展(待发表)
线粒体移植在治疗线粒体缺陷疾病中的研究进展
Advances of mitochondrial transplantation therapy for the mitochondrial deficiency diseases
投稿时间:2017-06-14  修订日期:2017-12-08
中文关键词:  线粒体移植,线粒体功能障碍,脑缺血,心肌缺血再灌注损伤,肿瘤
英文关键词:mitochondrial transplantation, mitochondrial dysfunction, cerebral ischemia,myocardial-ischemia-reperfusion injury, tumor
基金项目:国家自然科学基金联合基金重点项目(U1432248);科技部国家重点研发项目(2016YFC0904600);国家自然科学基金青年基金项目(11505245)
作者单位E-mail
杨世锋 兰州大学药学院 yangshf16@lzu.edu.cn 
孙超 中国科学院近代物理研究所 sunchao@impcas.ac.cn 
王玉佩 中国科学院近代物理研究所  
陈玉红 中国科学院近代物理研究所  
张倩婧 中国科学院近代物理研究所  
张红 中国科学院近代物理研究所 zhangh@impcas.ac.cn 
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中文摘要:
      线粒体是真核细胞中重要的细胞器,它是高等生命体赖以生存的能量来源.线粒体异常则可引起细胞甚至器官发生病变,越来越多的疾病被证实与线粒体功能障碍有关.线粒体移植是从患者正常组织分离线粒体然后注入线粒体损伤或缺失的部位,使损伤细胞得到救治、器官功能得以恢复的全新干预技术.线粒体移植作为一种新兴治疗方案在一些疾病干预的基础研究中崭露头角,尤其是在保护心脏缺血再灌注损伤领域已经发展到临床试验阶段.此文从线粒体起源出发,总结了仍处于实验阶段的几种线粒体移植方法,概述了线粒体移植在脑缺血引起神经元损伤保护领域、心肌缺血再灌注损伤保护领域和肿瘤治疗领域的研究进展,从分子层面探讨了线粒体损伤及线粒体移植修复的机理,并提出研发患者专属的“线粒体移植治疗生物制剂”的设想,旨在为线粒体缺陷有关疾病的治疗研究提供新的视角.
英文摘要:
      Mitochondrion are one of the most important organelles in eukaryotic cells, the main function of which is to provide energy for the survival of cells. The abnormal mitochondrial can cause lesions in cells and even organs, and a growing number of diseases have been linked to mitochondrial defects. Mitochondrial transplantation, an intrusive therapy, which isolated the mitochondria from the normal parts of the patient and then inject it into the damaged or absent areas, so that the injured cells can be treated and the organ functions return to normal. As a novel therapeutic strategy, the manner has emerged in the basic research of some diseases, especially in the field of acute myocardial ischemia reperfusion injury, which has been developed to the clinical trial stage. Based on the origin of mitochondria, several feasible methods of mitochondrial transplantation in the experimental phase were summarized. In addition, the protection of cerebral ischemia/induced neuronal injury and tumor therapy by mitochondria transplantation were also introduced. Moreover, the molecular mechanisms of mitochondrial damage and mitochondrial transplantation were discussed, and put forward the research ideas for developing targeted therapeutic biological agents for mitochondrial transplantation. The paper aims to provide a new perspective for curing of mitochondrial deficiency diseases.
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